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Proteins are the workhorses of the cell, executing a multitude of essential functions in all living organisms. However, when proteins misfold or become damaged, they can accumulate and cause a host of diseases, including neurodegenerative disorders like Alzheimer’s and Parkinson’s disease, as well as various forms of cancer. To prevent the buildup of these malfunctioning proteins, cells have developed complex mechanisms to degrade and recycle them. Among the innovative strategies emerging in this field is proatese, a novel class of molecules engineered to selectively target and eliminate specific proteins. This article will delve into the concept of proatese, exploring its key characteristics, therapeutic potential, challenges, and future directions in the realm of protein degradation.